The Indianapolis Colts will travel to Nashville in Week 3. The game time is set for 1:00 p.m. ET on Sunday, Sept. 26, at Nissan Stadium.
The contest will mark the 53rd all-time regular season matchup between the teams, with the Colts leading the series at 35-17. Last season, the teams split the series with the Titans winning the most matchup on Nov. 29, 2020 in Indianapolis, 45-26.