Giants vs. 49ers odds, line, spread: Thursday Night Football picks, NFL predictions by model on 164-117 roll

The San Francisco 49ers will try to get off to a rare 3-0 start  when they play their home opener against the New York Giants on Thursday Night Football. San Francisco (2-0), which has won 12 consecutive regular-season games, has begun a campaign with three straight victories just once in the last 25 seasons. The Giants (1-1) suffered an embarrassing 40-0 home loss to Dallas in their season-opener and trailed 20-0 at halftime in Arizona last week before matching a franchise-record by rallying from a 21-point and posting a 31-28 victory. New York could be without Saquon Barkley, however, after the star running back sprained his ankle against the Cardinals.

Kickoff from Levi’s Stadium is set for 8:15 p.m. ET. San Francisco is a 10-point favorite in the latest Giants vs. 49ers odds, while the over/under for total points scored is 44.5. Before making any 49ers vs. Giants picks, you need to see the NFL predictions and betting advice from SportsLine’s Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2023 NFL season on an incredible 164-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on an 18-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Giants and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Giants vs. 49ers: 

Giants vs. 49ers spread: San Francisco -10Giants vs. 49ers over/under: 44.5 points Giants vs……

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